Patterns of asthma symptoms and perceptions of harm from seasonal atmospheric events in rural Western Montana.

To characterize the frequency of and relationship between self-reported asthma symptoms and physician-diagnosed asthma, identify seasons associated with heightened symptoms, and describe the influence of seasonal atmospheric events and ambient environmental factors on asthma symptoms and perceptions of harm, a seven-county region of Western Montana was surveyed, utilizing a two-stage sampling method. Respondents were queried concerning asthma-related history, symptoms, and environmental concerns. Of 2,790 respondents, 12% reported physician-diagnosed asthma. Eighteen percent reported one or more and 9% reported two or more asthma-related symptoms. Over 70% of asthmatics reported worsened asthma symptoms during wildland-fire smoke exposure. Of those reporting summer as the season they experienced the greatest breathing problems, 81% reported breathing problems from wildland-fire smoke (p < 0.01). Of those reporting worsened symptoms in fall or winter, 61% reported breathing problems during winter inversions (p < 0.001).

An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring.

This investigation randomly sampled a fluorochemical manufacturing employee population to determine the distribution of serum fluorochemical levels according to employees' jobs and work areas. Previous analyses of medical surveillance data have not shown significant associations between fluorochemical production employees' clinical chemistry and hematology tests and their serum PFOS and perfluorooctanoate (PFOA, C(7)F(15)COO(-)) concentrations, but may have been subject to nonparticipation bias. A random sample of the on-site film plant employee population, where fluorochemicals are not produced, determined their serum concentrations also. Of the 232 employees randomly selected for serum sampling, 186 (80%) employees participated (n=126 chemical plant; n=60 film plant). Sera samples were extracted using an ion-pairing extraction procedure and were quantitatively analyzed for seven fluorochemicals using high-pressure liquid chromatography electrospray tandem mass spectrometry methods. Geometric means (in parts per million) and 95% confidence intervals (in parentheses) of the random sample of 126 chemical plant employees were: PFOS 0.941 (0.787-1.126); PFOA 0.899 (0.722-1.120); perfluorohexanesulfonate 0.180 (0.145-0.223); N-ethyl perfluorooctanesulfonamidoacetate 0.008 (0.006-0.011); N-methyl perfluorooctanesulfonamidoacetate 0.081 (0.067-0.098); perfluorooctanesulfonamide 0.013 (0.009-0.018); and perfluorooctanesulfonamidoacetate 0.022 (0.018-0.029). These geometric means were approximately one order of magnitude higher than those observed for the film plant employees.